As a front-end developer, I don’t know how many times I was given PSD file from a designer that was filled with layers and layers with blend modes. I don’t always look for them until I start wondering why my colors are off, even after using color picker tool to grab the exact RGB(A) values — blend modes.
According to medium.com, it looks like CSS Blend Modes could be the next big thing in Web Design, as they may be coming to a browser near you in 2014.